The t ( 1 ; 14 ) ( p 34 ; ql l ) Is Nonrandom and Restricted t o T - c e l l Acute Lymphoblastic Leukemia : A Pediatric Oncology Group Study
نویسنده
چکیده
We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(l;14)(p34; q l 1 1 in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single Pediatric Oncology Group classification study (POG 8600) between January 1986 and February 1989. The frequency of the t(l;14) was 3% (5 of 168 cases) in children with T-cell ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the t(l;14) was accompanied by a deletion of the long arm
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تاریخ انتشار 2003